Triglyceride down-regulates matrix metalloprotease-12 expression in THP-1 macrophages through activation of the NF-κB pathway

Autor:	Dong Hyun Lee, Yoonjung Cho, Cheol-Ho Pan, Ki Jong Rhee, Yoon Suk Kim, Jaewon Lim, Hyun-Kyung Kim, Byung Chul Jung
Rok vydání:	2013
Předmět:	Triglyceride Cell migration NF-κB Cellular level Matrix metalloproteinase Biology Biochemistry Cell biology chemistry.chemical_compound chemistry Genetics THP1 cell line Wound healing assay Molecular Biology Cell signaling pathways
Zdroj:	Genes & Genomics. 35:405-409
ISSN:	2092-9293 1976-9571
Popis:	Triglyceride (TG) is known to be associated with inflammatory diseases including atherosclerosis. At the cellular level, TG can act as an immunomodulatory stimulus for macrophages. In this study we show that TG treatment of PMA-differentiated macrophages resulted in down-regulation of MMP-12 expression in a time- and dose-dependent manner. MMP-19 expression was unaffected by TG treatment. Using a variety of chemical inhibitors for cell signaling pathways we demonstrate that TG-induced down-regulation of MMP-12 occurs in part by activation of the NF-κB pathway. Finally, TG treatment of PMA-differentiated macrophages decreased cell migration in a wound healing assay. Taken together our data suggests that one function of TG is to modulate macrophage migration in tissues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7000ea2a96c62322aff97afeb18bfae3 https://doi.org/10.1007/s13258-013-0105-5 Zobrazit plný text záznamu Full text from SpringerLink