In Vivo and In Vitro Evidence for the Antihyperuricemic, Anti-inflammatory and Antioxidant Effects of a Traditional Ayurvedic Medicine, Triphala
| Autor: | Supachoke Mangmool, Narawat Nuamnaichati, Prasob-orn Rinthong, Hitoshi Sato, Bunleu Sungthong, Vilasinee Hirunpanich Sato |
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| Rok vydání: | 2017 |
| Předmět: |
Pharmacology
Antioxidant Ayurvedic medicine Traditional medicine business.industry medicine.drug_class medicine.medical_treatment Anti inflammation Plant Science General Medicine 030226 pharmacology & pharmacy In vitro Anti-inflammatory 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Complementary and alternative medicine chemistry In vivo 030220 oncology & carcinogenesis Drug Discovery medicine Xanthine oxidase business Triphala |
| Zdroj: | Natural Product Communications. 12:1934578X1701201 |
| ISSN: | 1555-9475 1934-578X |
| Popis: | The objectives of the present study were to demonstrate the antihyperuricemic effect of triphala, a formulation of traditional Ayurvedic medicine, in potassium oxonate-induced hyperuricemic mice in vivo, and to examine its inhibitor effects on xanthine oxidase (XOD), inflammatory mediators and DPPH radicals in vitro. The water extract of triphala was determined to contain the total phenolics and total flavonoids of 317.6 ± 9.2 mg GAE/g and 7.73 ± 0.26 mg QE/g, respectively. Oral administrations of triphala significantly reduced the plasma uric acid levels of potassium oxonate-induced hyperuricemic mice at doses of 1,000 and 1,500 mg/kg, as compared with control ( p50 values for inhibition of DPPH radical formation was calculated to be 21.9 ± 2.50 μg/mL. Antioxidant activities of triphala were determined to be 0.81 ± 0.07 g TEAC/g and 6.78 ± 0.29 mmol/100g, respectively, as assessed by ABTS and FRAP assays. In conclusion, this study provided in vivo and in vitro mechanistic evidence for the antihyperuricemic, antioxidative and anti-inflammatory effects of triphala for the first time, rationalizing its therapeutic usage for the treatment of hyperuricemia of gout. |
| Databáze: | OpenAIRE |
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