Synthesis and biological evaluation of novel 1,3-diphenylurea quinoxaline derivatives as potent anticancer agents
| Autor: | Hai-Tao Tang, Li Yang, Xiao-Lin Cao, Zu-Yu Mo, Gui-Zhen Li, Xi-Lin Ouyang, Yao Gu, Ying-Ming Pan |
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| Rok vydání: | 2021 |
| Předmět: |
biology
010405 organic chemistry Chemistry Organic Chemistry Carbon-13 NMR biology.organism_classification 01 natural sciences Combinatorial chemistry 0104 chemical sciences HeLa 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Quinoxaline Mechanism of action Cell culture medicine Bioorganic chemistry MTT assay General Pharmacology Toxicology and Pharmaceutics medicine.symptom Cytotoxicity |
| Zdroj: | Medicinal Chemistry Research. 30:1496-1511 |
| ISSN: | 1554-8120 1054-2523 |
| DOI: | 10.1007/s00044-021-02745-2 |
| Popis: | A series of 1,3-diphenylurea quinoxaline derivatives were synthesized and characterized by 1H, 13C NMR, and HR-ESI-MS analyses. In vitro cytotoxicity of the synthesized compounds was evaluated by MTT assay against MGC-803, H460, T-24, HeLa, HepG2, and SMMC-7721 human cancer cell lines. The results showed that most of the compounds exhibited effective cytotoxicity to the tested cancer cell lines. The mechanism of action of the two best active quinoxaline derivatives, compounds 2d and 2g was also investigated. They may be potent anticancer agents. |
| Databáze: | OpenAIRE |
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