Aging Aorta—Cellular Mechanisms
| Autor: | Mircea Ifrim, Ecaterina Bontas, Dan Riga, Florentina Radu-Ionita, Vasile Murgu, Sorin Riga, Dragos Savoiu, Romi Bolohan, Constantin Silvestru, Iancu Mocanu, Ion C. Ţintoiu, Andrei Rosu, Ambrose S. Kibos, Daniel Cochior |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Senescence Aorta medicine.medical_specialty Vascular smooth muscle Contraction (grammar) business.industry Disease 030204 cardiovascular system & hematology medicine.disease Extracellular matrix 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.artery Internal medicine medicine Cardiology Arterial stiffness Endothelial dysfunction business |
| DOI: | 10.1016/b978-0-12-809979-7.00001-8 |
| Popis: | A significant risk factor for cardiovascular diseases is aging; an independent prediction factor for cardiovascular death is arterial stiffness. To reiterate, aged aorta is defined by endothelial dysfunction with the alteration of contraction and migration of vascular smooth muscle cells, production and contention of extracellular matrix, with its proliferation and senescence. As widely validated, the cellular mechanisms that caused alteration in the aged vessels have the same significance for the development of cardiovascular disorders such as hypertension or atherosclerosis. For that reason, the National Institute of Aging stress on molecular, genetic, cellular, and enzymatic research approaches for studying about aging aorta and aorta stiffness. As a result, amplified arterial stiffness should be regarded as a biomarker of aging and cardiovascular disease. |
| Databáze: | OpenAIRE |
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