Preparation of 7-modified docetaxel analogs using electrochemistry

Autor:	Alain Commercon, Jean-Dominique Bourzat, Herve Bouchard, Jean-Pierre Pulicani
Rok vydání:	1994
Předmět:	Organic Chemistry Hydrochloric acid Electrochemistry Biochemistry Taxoid chemistry.chemical_compound Acetic acid Docetaxel chemistry Drug Discovery medicine Organic chemistry Lithium chloride Methanol Sodium acetate medicine.drug Nuclear chemistry
Zdroj:	Tetrahedron Letters. 35:9709-9712
ISSN:	0040-4039
DOI:	10.1016/0040-4039(94)88366-1
Popis:	The electrochemical reduction of 7α-iodo docetaxel at E-1.3V vs. SCE in methanol in the presence of lithium chloride and hydrochloric acid leads predominantly to 7-deoxy-docetaxel 9. When the electroreduction is conducted at E-1.7V vs. SCE in the presence of sodium acetate and acetic acid, the cyclopropanol-containing taxoid 10 is formed in good yield. Electrochemical reduction of 7-deoxy-docetaxel at C-10 is also reported. All these docetaxel analogs retain biological activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6fdffccf46c10d2b05486ed58eb78b65 https://doi.org/10.1016/0040-4039(94)88366-1 Zobrazit plný text záznamu