Use of Gene-Activated Demineralized Bone Allograft in the Therapy of Ulnar Pseudarthrosis. Case Report
| Autor: | Damir Galimov, Oleg V. Teplov, Ruslan Masgutov, M. A. Chekunov, Margarita N. Zhuravleva, R. Z. Salikhov, Galina Masgutova, Albert A. Rizvanov, Yuri Plakseichuk |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Callus formation VEGF receptors Biomedical Engineering Bioengineering Bone morphogenetic protein 2 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine biology business.industry Demineralized bone matrix Ulna medicine.disease Surgery Vascular endothelial growth factor Pseudarthrosis 030104 developmental biology medicine.anatomical_structure chemistry biology.protein Demineralized bone business 030217 neurology & neurosurgery |
| Zdroj: | BioNanoScience. 7:194-198 |
| ISSN: | 2191-1649 2191-1630 |
| DOI: | 10.1007/s12668-016-0325-7 |
| Popis: | This paper presents a clinical case of successful ulnar pseudarthrosis treatment using a gene-activated bone allograft containing VEGF (vascular endothelial growth factor) and BMP2 (bone morphogenetic protein 2) in the form of a multicystron plasmid. Demineralized bone matrix with applied recombinant plasmid DNA was grafted into the bone defect using the classical open surgical approach. Two months after the surgery, the patient noticed the disappearance of pain including pain during activity. On X-rays of ulna, signs of union in the form of callus formation were found. |
| Databáze: | OpenAIRE |
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