Design of a modified electrospinning for the in-situ fabrication of 3D cotton-like collagen fiber bundle mimetic scaffold
| Autor: | Jeong In Kim, Cheol Sang Kim, Ju Yeon Kim, Chan Hee Park |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Scaffold
Fabrication Materials science Mechanical Engineering technology industry and agriculture 02 engineering and technology Matrix (biology) 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Electrospinning 0104 chemical sciences Extracellular matrix chemistry.chemical_compound Chemical engineering chemistry Mechanics of Materials Polycaprolactone General Materials Science Fourier transform infrared spectroscopy 0210 nano-technology Cell adhesion |
| Zdroj: | Materials Letters. 236:521-525 |
| ISSN: | 0167-577X |
| DOI: | 10.1016/j.matlet.2018.10.087 |
| Popis: | The ability to mimic the topography of aligned collagen fiber bundles (A-CFB) that form the structural basis for the extracellular matrix (ECM) can be an important step in the fabrication of engineered scaffolds. Because the cell adhesion to the surface topography involve cell adhesion localized structures, topographical features, which mimics the A-CFB of the matrix can be a significant factor for cell activities. In this study, we present a novel method for the fabrication of low-density electrospun fibers mimicking A-CFB constructs. The three dimensional (3D) cotton-like A-CFB mimetic scaffold (3D-CACMS) of a mixture of lactic acid (LA) and polycaprolactone (PCL) was prepared by multiple pins rotator electrospinning (MPRES), followed by selective leaching of LA. The results of SEM, FTIR, TGA, and DSC revealed the physicochemical properties of the as-fabricated scaffold. This 3D-CACMS attempt to mimic A-CFB and can potentially meet the requirements for practical use of biomedical engineering. |
| Databáze: | OpenAIRE |
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