Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life

Autor:	Brian D. Rudd, Cybelle Tabilas, Norah L. Smith, Xiaojing Liu, Jocelyn Wang, Jason W. Locasale
Rok vydání:	2019
Předmět:	Effector Intracellular parasite Transgene Immunology Metabolism Biology Cell biology 03 medical and health sciences 0302 clinical medicine Immunity Immunology and Allergy Cytotoxic T cell Glycolysis CD8 030215 immunology
Zdroj:	The Journal of Immunology. 203:2571-2576
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.1900426
Popis:	Neonates often develop poor immunity against intracellular pathogens. Because CD8+ T cells are essential for eliminating infectious agents, it is crucial to understand why they behave differently in early life. Previous studies in mice have demonstrated that neonatal CD8+ T cells fail to form memory because of an intrinsic propensity to differentiate into short-lived effectors. However, the underlying mechanisms remain undefined. We now show that neonatal CD8+ T cells exhibit higher glycolytic activity than adult CD8+ T cells postinfection, which may be due to age-related differences in Lin28b expression. Importantly, when glycolysis is pharmacologically inhibited, the impaired formation of neonatal memory CD8+ T cells can be restored. Collectively, these data suggest that neonatal CD8+ T cells are inherently biased toward undergoing glycolytic metabolism postinfection, which compromises their ability to develop into memory CD8+ T cells in early life.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6fbf7fcc55acac2f17e1d042a8bf5654 https://doi.org/10.4049/jimmunol.1900426 Zobrazit plný text záznamu