Adipose Tissue Transferrin and Insulin Resistance
| Autor: | Felipe R. Lorenzo, Neeraj Sharma, Carl D. Langefeld, Lipika Salaye, Shalini Jain, Swapan K Das, Donald A. McClain, Mary E. Comeau |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Gene knockdown biology Endocrinology Diabetes and Metabolism Glucose uptake Glucose transporter Adipose tissue medicine.disease Chemokine activity Endocrinology Insulin resistance chemistry Transferrin Internal medicine Internal Medicine biology.protein medicine GLUT4 |
| Zdroj: | Diabetes. 67 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/db18-1760-p |
| Popis: | Iron is an important micronutrient involved in several metabolic processes, and excessive iron is a risk factor for insulin resistance (IR) and diabetes. To define the genetic regulation of iron metabolism and its role in IR, we used gene expression, genotype, and insulin sensitivity data from an African American cohort (AAGMEx, N=256). Among the genes in a manually curated list of 62 transcripts representing iron homeostasis genes, expression of 32 in adipose tissue showed significant correlation with SI (p70%) of 465 genes, involved in mitochondrial function (CPT1B, UCP2), glucose transport (GLUT4), Wnt-pathway/insulin sensitivity (SFRP4, SFRP1), chemokine activity/cell-cell interaction (CXCL1, CXCL12, ICAM1), and genes with possible roles in obesity (CES1, RARRES2). Knockdown of TF mRNA in differentiated SGBS cells impaired mitochondrial respiration (49±10% reduction of maximal oxygen consumption rate) and caused a 34±4% reduction in maximal insulin-stimulated glucose uptake (p In summary, genetic regulation of transferrin expression in adipose tissue plays a novel role in regulating insulin sensitivity. Disclosure D. McClain: None. N.K. Sharma: None. F. Lorenzo: None. S. Jain: None. C.D. Langefeld: None. M.E. Comeau: None. L. Salaye: None. S.K. Das: None. |
| Databáze: | OpenAIRE |
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