Structural modification, fungicidal and insecticidal activity of 5-arylbenzofuran neolignan from Magnolia officinalis
| Autor: | Yangjie Yi, Chuyun Long, Aiping Liu, Ding Lin, Li Kangming, Zhongzhong Yan, Jiao Ye, Ai-Xi Hu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
biology
Low toxicity Traditional medicine 010405 organic chemistry Chemistry Plant Science Secondary metabolite biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Aphis Fungicide 010404 medicinal & biomolecular chemistry Magnolia officinalis chemistry.chemical_compound medicine Agronomy and Crop Science Lead compound Biotechnology medicine.drug |
| Zdroj: | Phytochemistry Letters. 30:53-57 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2019.01.016 |
| Popis: | As shown in a number of previous researches, the extracts of Magnolia officinalis exhibited broad-spectrum fungicidal and insecticidal activity. In our preliminary study, 5-arylbenzofuran neolignans, the secondary metabolite of Magnolia officinalis, was found to inherit the activity of Magnolia officinalis. For developing novel agrochemicals, natural 5-arylbenzofuran neolignan was selected as lead compound. After structural optimization, the fungicidal and insecticidal activity and selectivity were significantly improved. Compounds 5a, 5b, 6c and 6d displayed similar or equivalent activity compared with the positive controls against corresponding fungi or pests. Especially, compounds 6c and 6d exhibited the most promising insecticidal ability against Aphis fabae with the LC50 values of 3.56 mg/L and 5.96 mg/L, respectively. The preliminary structure-activity relationship was obtained, and the promising derivatives showed low toxicity in the model of human cells. The results of research indicated great potential of 5-arylbenzofuran neolignan derivatives in the field of fungicide and insecticide. |
| Databáze: | OpenAIRE |
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