Left Ventricular Hypertrophy in Chronic Pressure Load Due to Spontaneous Essential Hypertension I. Left Ventricular Function, Left Ventricular Geometry, and Wall Stress
| Autor: | S. B. Bürger, B. E. Strauer |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Pressure overload
medicine.medical_specialty business.industry Essential hypertension medicine.disease Left ventricular hypertrophy Pulmonary artery banding Muscle hypertrophy Coronary artery disease Blood pressure Internal medicine cardiovascular system Cardiology Ventricular pressure Medicine business |
| Zdroj: | The Heart in Hypertension ISBN: 9783540104964 |
| DOI: | 10.1007/978-3-642-67922-3_2 |
| Popis: | Essential hypertension represents the most frequent form of left ventricular pressure overload and hypertrophy in man. Previous studies in patients with essential hypertension have shown normal left ventricular function at rest and during exercise as long as coronary artery disease, regional wall motion abnormalities, or left ventricular dilatation are absent [17, 18]. In contrast, most experimental findings have demonstrated reduced myocardial contractility in pressure hypertrophy due to pulmonary artery banding [7, 16], aortic constriction [4, 9], or experimental renal hypertension [1, 9]. In contrast to the rapid onset of pressure overload due to outflow tract banding, spontaneously hypertensive rats (SHR), originally developed by Okamoto and Aoki [12], represent a model for slowly proceeding left ventricular pressure overload and in this way most closely resemble left ventricular pressure overload and hypertrophy in essential hypertension in man. Accordingly, the course of development of hypertensive hypertrophy can be systematically investigated by this experimental model. |
| Databáze: | OpenAIRE |
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