Serum Free Insulin-Like Growth Factor I (IGF-I), Total IGF-I, and IGF-Binding Protein-3 Concentrations in Normal Children and Children with Growth Hormone Deficiency1
| Autor: | Tsuyoshi Miyata, Chiaki Tada, Nobuyasu Kawai, Yoshiki Seino, Masanori Oka, Susumu Kanzaki, Yoshitaka Yamanaka, Syouko Takano-Watou |
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| Rok vydání: | 1999 |
| Předmět: |
Bone growth
medicine.medical_specialty Immunoradiometric assay biology business.industry Endocrinology Diabetes and Metabolism medicine.medical_treatment Growth factor Biochemistry (medical) Clinical Biochemistry medicine.disease Biochemistry Insulin-like growth factor-binding protein Growth hormone deficiency Insulin-like growth factor Endocrinology El Niño Internal medicine Blood plasma medicine biology.protein business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 84:82-89 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.84.1.5407 |
| Popis: | To evaluate the role of serum free or unbound insulin-like growth factor I (IGF-I) on bone growth, we measured serum free IGF-I levels in 354 healthy children and adults (193 males and 161 females, aged 0–40 yr) and in 21 prepubertal GH-deficient (GHD) children (complete GHD, n = 5; partial GHD, n = 16) using a recently developed immunoradiometric assay. We obtained the following results. 1) In the normal children, the serum free IGF-I levels were low in infancy ( These results show that free IGF-I in the serum has an essential role in bone formation because the higher free IGF-I levels were observed when the growth rate accelerated. The measurement of serum free IGF-I may become a useful tool for both diagnosing GH deficiency and predicting growth responses to long term GH therapy. |
| Databáze: | OpenAIRE |
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