| Autor: | Hiromi Tanii, Natsuko Sato, Satoshi Kobayashi, Eiichi Fuse, Akitoshi Hashimoto, Takashi Kuwabara, Yuichi Sugiyama |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pharmacology
endocrine system Chemistry Dissociation rate Organic Chemistry Pharmaceutical Science 7-hydroxystaurosporine Plasma protein binding Anticancer drug Physiological model Pharmacokinetics Biochemistry otorhinolaryngologic diseases α1 acid glycoprotein Molecular Medicine Distribution (pharmacology) Pharmacology (medical) Biotechnology |
| Zdroj: | Pharmaceutical Research. 17:553-564 |
| ISSN: | 0724-8741 |
| DOI: | 10.1023/a:1007512832006 |
| Popis: | Purpose. The extremely low clearance and small distribution volumeof UCN-01 in humans could be partly due to the high degree of bindingto hAGP (1,2). The quantitative effects of hAGP on the pharmacokineticsof UCN-01 at several levels of hAGP and UCN-01 were estimatedin rats given an infusion of hAGP to mimic the clinical situation anda physiological model for analysis was developed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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