Synthesis of novel 1,2- and 2-substituted benzimidazoles with high antibacterial and antioxidant activity
| Autor: | Ilona Jonuškienė, Vytautas Mickevičius, Artūras Peleckis, Ingrida Tumosienė, Jūratė Šiugždaitė, Zigmuntas Jonas Beresnevičius, Rita Vaickelionienė, Kristina Kantminienė |
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| Rok vydání: | 2018 |
| Předmět: |
Benzimidazole
Antioxidant biology 010405 organic chemistry medicine.medical_treatment Bacillus cereus General Chemistry 010402 general chemistry medicine.disease_cause biology.organism_classification 01 natural sciences Chemical synthesis Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound chemistry medicine Moiety Antibacterial activity Escherichia coli Antibacterial agent |
| Zdroj: | Monatshefte für Chemie - Chemical Monthly. 149:577-594 |
| ISSN: | 1434-4475 0026-9247 |
| Popis: | Benzimidazole derivatives are potential candidates for drug development. They are efficiently synthesized and possess various biological properties including antibacterial activity. A series of functionalized benzimidazole derivatives bearing N-(4-chloro- or fluorophenyl)pyrrolidin-2-one or N-(4-chloro- or fluorophenyl)aminobutanoic acid moiety were synthesized. Compounds possessing a very high antibacterial activity, comparable to that of a commercial antibacterial agent oxytetracycline, against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Bacillus cereus were identified. Some of the synthesized compounds exhibited significant antioxidant activity. |
| Databáze: | OpenAIRE |
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