Obesity-associated methylation in breast tumors: a possible link to disparate outcomes?
| Autor: | Whitney L Do, Mylin A. Torres, Lauren E. McCullough, Sheryl Gabram-Mendola, Uma Krishnamurti, Jasmine Miller-Kleinhenz, Olivia D'Angelo, Keerthi Gogineni, Karen N. Conneely |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty business.industry Estrogen receptor Methylation medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Breast cancer CpG site 030220 oncology & carcinogenesis Internal medicine DNA methylation medicine Epigenetics Risk factor business Body mass index |
| Zdroj: | Breast Cancer Research and Treatment. 181:135-144 |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-020-05605-6 |
| Popis: | As a primary risk factor and modifier of breast cancer incidence and prognosis, obesity may contribute to race disparities in breast cancer outcomes. This study examined association between obesity and DNA methylation in non-Hispanic Black and White women diagnosed with breast cancer. Genome-wide DNA methylation was measured in the breast cancer tumor tissue of 96 women using the EPIC array. To examine the association between obesity and tumor methylation, linear regression models were used—regressing methylation β value for each cytosine and guanine (CpG) site on body mass index adjusting for covariates. Significance was set at false discovery rate (FDR) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink