Increased cytokine release by leucocytes in survivors of stroke at young age
| Autor: | M. Aulmann, Tobias Brandt, Christoph Lichy, H. Meiser, Florian Buggle, Caspar Grond-Ginsbach, Armin J. Grau |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
biology Vascular disease business.industry medicine.medical_treatment Clinical Biochemistry Ischemia General Medicine medicine.disease Biochemistry Gastroenterology Cytokine Internal medicine Immunology medicine biology.protein Myocardial infarction Young adult Risk factor Interleukin 6 business Stroke |
| Zdroj: | European Journal of Clinical Investigation. 31:999-1006 |
| ISSN: | 0014-2972 |
| DOI: | 10.1046/j.1365-2362.2001.00923.x |
| Popis: | Background Enhanced stimulus-induced release of pro-inflammatory cytokines by leucocytes may contribute to the pathogenesis of ischaemic stroke. Design We investigated the lipopolysaccharide-induced release of interleukin-1β (IL-1β), IL-6, IL-8, and tumour necrosis factor-α (TNF-α) in whole blood from 20 patients with a history of ischaemic stroke under the age of 50, 20 patients with a history of cervical artery dissection (CAD) and 21 age- and sex-matched healthy control subjects. Results Release of IL-8 was higher (P = 0.006) and release of TNF-α and IL-6 tended to be higher (P < 0.1) in young stroke patients than in control subjects. No increased release existed in CAD patients. Vascular risk factors or history of infection before stroke did not modify IL-8 production. A common T(250) → A polymorphism in the IL-8 gene promotor was newly identified but did not correlate with the variability of IL-8 release. The C(260) → T polymorphism in the gene of the monocytic LPS-receptor CD14 - a risk factor for myocardial infarction - was not associated with increased cytokine release. Conclusions We conclude that high inducible release of IL-8 - and possibly of TNF-α and IL-6 - may contribute to the odds of ischaemic stroke in young adults. |
| Databáze: | OpenAIRE |
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