ChemInform Abstract: Visible Light-Induced Trifluoromethylation and Perfluoroalkylation of Cysteine Residues in Batch and Continuous Flow

Autor:	Timothy Noël, Xiao-Jing Wei, Volker Hessel, Cecilia Bottecchia, Koen P. L. Kuijpers
Rok vydání:	2016
Předmět:	chemistry.chemical_classification chemistry Trifluoromethylation Yield (chemistry) Photocatalysis Moiety Quantum yield General Medicine Photochemistry Alkyl Visible spectrum Cysteine
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201652399
Popis:	We report a visible light-induced trifluoromethylation and perfluoroalkylation for cysteine conjugation using Ru(bpy)32+ as photocatalyst and inexpensive RFI as coupling partner. The protocol allows the introduction of a variety of perfluoro alkyl groups (C1–C10) and a CF2COOEt moiety. The reaction is high yielding (56–94% yield) and fast (2 h in batch, 12 examples). Process intensification in a photomicroreactor accelerated the reaction (5 min reaction time) and increased the yields (8 examples). Quantum yield investigations support a radical chain mechanism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6f7e7b787b54b7cf721063dd3a4e5e6f https://doi.org/10.1002/chin.201652399 Zobrazit plný text záznamu Plný text