Propionibacterium acnes-associated Sarcoidosis Possibly Initially Triggered by Interferon-alpha Therapy
| Autor: | Takuji Suzuki, Naomi Nakano, Mamitaro Ohtsuki, Masashi Bando, Yoshinobu Eishi, Michiru Sawahata, Tetsuo Yamaguchi, Yasumaro Fujiki, Koichi Hagiwara, Keisuke Uchida |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Multiple Pulmonary Nodules
Pathology medicine.medical_specialty biology medicine.diagnostic_test Mediastinal lymphadenopathy business.industry Ribavirin Alpha interferon General Medicine 030204 cardiovascular system & hematology biology.organism_classification medicine.disease 03 medical and health sciences Propionibacterium acnes chemistry.chemical_compound 0302 clinical medicine chemistry Biopsy Internal Medicine medicine 030211 gastroenterology & hepatology Sarcoidosis business Uveitis |
| Zdroj: | Internal Medicine. 60:777-781 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.5281-20 |
| Popis: | A 46-year-old woman with uveitis was referred to our respiratory diseases department in July 2018. Her medical history included transient bilateral hilar mediastinal lymphadenopathy (BHL) and multiple pulmonary nodules in May 2013 during pegylated interferon-alpha and ribavirin treatment for chronic hepatitis C infection. Five years post-treatment, chest X-ray revealed BHL and nodular recurrence. A biopsy of the subcutaneous buttock nodules revealed scattered non-caseating epithelioid granulomas with positive PAB immunohistochemical staining. This seem to be the first report of Propionibacterium acnes-associated sarcoidosis possibly initially triggered by interferon-alpha therapy. Understanding the mechanisms underlying interferon-triggered P. acnes-associated sarcoidosis may clarify the sarcoidosis immunopathogenesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|