Movement of spotted fever rickettsiae through tick host cells in vitro
| Autor: | S. F. Hayes, J. Cummings, U. G. Munderloh, T. J. Kurtti |
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| Rok vydání: | 1996 |
| Předmět: | |
| Zdroj: | Proceedings, annual meeting, Electron Microscopy Society of America. 54:810-811 |
| ISSN: | 2690-1315 0424-8201 |
| DOI: | 10.1017/s0424820100166518 |
| Popis: | Spotted fever group (SFG) rickettsiae are obligate intracellular prokaryotes that include tick-borne pathogens of animals and man as well as organisms that live in symbiotic association with their tick hosts. A striking feature of the behavior of pathogenic rickettsiae in the vertebrate is their ability to quickly disseminate between cells from the original site of entry shortly after infection, and before severe lesions are detected. Similarly, ticks become systemically infected with SFG rickettsiae, indicating that an efficient mechanism of dispersal also exists in the vector. This is accomplished despite the fact that rickettsiae are not motile.Kadurugamuwa et al. (1991) have used light and electron microscopy to show that Shigella flexneri utilize host cytoskeletal components to travel through cytoplasmic extensions and penetrate into neighboring cells. Using mammalian cells cultured in vitro, Heinzen et al. (1993) have demonstrated that SFG rickettsiae cause host cell actin polymerization at one rickettsial pole causing them to be propelled through the cytoplasm, and to transfer rapidly from cell to cell. |
| Databáze: | OpenAIRE |
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