Resolved 2-arylcyclohexylamines: Effects on reserpine akinesia and central nervous system monoamine synthesis

Autor:	M Lundmark, S. Hjorth, S Sundell, B. Largent, Kjell A. Svensson, Håkan Wikström, Bengt Andersson, A Carlsson
Rok vydání:	1993
Předmět:	Pharmacology Chemistry Organic Chemistry Central nervous system Absolute configuration Stimulation Biological activity General Medicine Reserpine Serotonergic Monoamine neurotransmitter medicine.anatomical_structure Dopamine Drug Discovery medicine medicine.drug
Zdroj:	European Journal of Medicinal Chemistry. 28:63-69
ISSN:	0223-5234
DOI:	10.1016/0223-5234(93)90079-t
Popis:	A series of cis- and trans-2-arylcyclohexylamines were synthesized and resolved. The absolute configuration was determined by single-crystal X-ray analysis. Some of the compounds, and especially racemic 2-(3-hydroxyphenyl)-N,N-dipropylcyclohexylamine showed a marked locomotor stimulation in reserpinized rats. However, these compounds displayed only minor effects on dopamine and 5-hydroxytryptamine synthesis rates, indicating a non-dopaminergic and/or serotonergic mechanism for this stimulation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6f656b22ec4879af11407fe27f5d9e46 https://doi.org/10.1016/0223-5234(93)90079-t Zobrazit plný text záznamu