| Autor: | P. A. Kaliman, I. V. Nikitchenko, O. A. Sokol, E. V. Strel'chenko |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
chemistry.chemical_classification
Antioxidant biology medicine.medical_treatment Cytochrome P450 General Medicine medicine.disease medicine.disease_cause Biochemistry Chloride Hemolysis Heme oxygenase chemistry.chemical_compound Enzyme chemistry medicine biology.protein Heme Oxidative stress medicine.drug |
| Zdroj: | Biochemistry (Moscow). 66:77-82 |
| ISSN: | 0006-2979 |
| Popis: | Activities of heme oxygenase and tryptophan-2,3-dioxygenase and cytochrome P450 content in liver as well as absorption of the Soret band and optical density at 280 nm in serum were determined 2 and 24 h after administration of HgCl2 and CoCl2 and after co-administration of the metal salts with a-tocopherol. Administration of HgCl2 and CoCl2 increased the contents of hemolysis products in the serum, induced heme oxygenase, and decreased cytochrome P450 content in the liver. Injection of HgCl2 increased the activity of tryptophan-2,3-dioxygenase holoenzyme and enzyme saturation with the heme, but administration of CoCl2 decreased these parameters. Pretreatment with a-tocopherol completely blocked the changes induced by HgCl2 after 24 h. Induction of heme oxygenase induced by CoCl2 was not blocked by a-tocopherol, but this antioxidant normalized the increase in the level of hemolysis products in the serum and decrease in tryptophan-2,3-dioxygenase holoenzyme activity and cytochrome P450 content. Mechanisms of regulation of heme oxygenase by mercury and cobalt ions are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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