Synthesis and Neurotropic Activity of Piperazino-Derivatives of Pyrano[3,4-c]Pyridines

Autor:	I. M. Nazaryan, R. G. Paronikyan, Samvel N. Sirakanyan, E. K. Akopyan, A. A. Ovakimyan, A. G. Akopyan
Rok vydání:	2019
Předmět:	Pharmacology 010405 organic chemistry medicine.drug_class medicine.medical_treatment Pharmacology toxicology Neurotoxicity medicine.disease 01 natural sciences Anxiolytic Open field 0104 chemical sciences 010404 medicinal & biomolecular chemistry Piperazine chemistry.chemical_compound Anticonvulsant chemistry Drug Discovery medicine Organic chemistry Antagonism
Zdroj:	Pharmaceutical Chemistry Journal. 53:495-499
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-019-02026-8
Popis:	Methods were developed for synthesizing new substituted piperazine derivatives from chloropyrano- [3,4-c]pyridines. Pharmacological screening of the synthesized compounds used the well-known corazole antagonism and open field tests. The rotating rod test was used to evaluate the neurotoxicity of the compounds. The tested compounds displayed neurotropic activity. Several compounds of this series exhibited pronounced anticonvulsant and anxiolytic activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6f54b11ed34cbaed5dac3870a5a8b66e https://doi.org/10.1007/s11094-019-02026-8 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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