Efficiency Improvement of Gelatin-Based Wound Dressings by Silk Fibroin and Chitosan
| Autor: | Suwichchaya Puntawang, Kittiya Thunsiri, Wassanai Wattanutchariya |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Materials science
food.ingredient integumentary system Polymer science Mechanical Engineering Fibroin 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Gelatin 0104 chemical sciences Chitosan chemistry.chemical_compound food chemistry Mechanics of Materials General Materials Science 0210 nano-technology |
| Zdroj: | Materials Science Forum. 995:97-102 |
| ISSN: | 1662-9752 |
| DOI: | 10.4028/www.scientific.net/msf.995.97 |
| Popis: | Wound healing is a natural process of human body. When the wound size exceeds the critical point for naturally body healing, the fibrous tissue will play their parts and created a scar. Therefore, extra treatment has been added to eliminate the body limitations. Currently, there are a lot of commercial bioactive wound healing and dressing due to its physiological and biological abilities. In wound healing process, high moisture condition is also required. In order to accelerate the wound healing process, Tissue engineering (TE) is recommended. The increasing of cell proliferation by TE will be increased the chance for wound healing acceleration. In this study, the combination of Gelatin (Gel), Chitosan (CS) and Silk Fibroin (SF) were varied mixed in 10 ratios and fabricated the structure by lyophilisation technique. The elastic ability, biodegradability, structure and pore morphology, porosity, swelling ability, and biotoxicity were observed in each ratio. Gel provided highest elastic ability and biodegradability. The addition of SF and CS in Gel decreased biodegradation rate and activate fibroblast cell proliferation. Therefore, CS and SF could increase efficiency of gelatin-base wound dressings for a variety of utilization. |
| Databáze: | OpenAIRE |
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