Curcumin attenuates memory deficits and the impairment of cholinergic and purinergic signaling in rats chronically exposed to cadmium
| Autor: | Pauline da Costa, Jessié Martins Gutierres, Fabiano B. Carvalho, Maribel Antonello Rubin, Fátima Husein Abdalla, Jucimara Baldissarelli, Jamile F. Gonçalves, Amanda Maino Fiorenza, Vera Maria Morsch, Michelle Melgarejo da Rosa, Cinthia Melazzo de Andrade, Thaís R. Mann, Maria Rosa Chitolina Schetinger |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Nucleotidase activity Health Toxicology and Mutagenesis medicine.medical_treatment General Medicine Management Monitoring Policy and Law Pharmacology Toxicology Acetylcholinesterase Neuroprotection Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry Curcumin medicine Cholinergic Saline 030217 neurology & neurosurgery Whole blood |
| Zdroj: | Environmental Toxicology. 32:70-83 |
| ISSN: | 1520-4081 |
| DOI: | 10.1002/tox.22213 |
| Popis: | This study investigated the protective effect of curcumin on memory loss and on the alteration of acetylcholinesterase and ectonucleotidases activities in rats exposed chronically to cadmium (Cd). Rats received Cd (1 mg/kg) and curcumin (30, 60, or 90 mg/kg) by oral gavage 5 days a week for 3 months. The animals were divided into eight groups: vehicle (saline/oil), saline/curcumin 30 mg/kg, saline/curcumin 60 mg/kg, saline/curcumin 90 mg/kg, Cd/oil, Cd/curcumin 30 mg/kg, Cd/curcumin 60 mg/kg, and Cd/curcumin 90 mg/kg. Curcumin prevented the decrease in the step-down latency induced by Cd. In cerebral cortex synaptosomes, Cd-exposed rats showed an increase in acetylcholinesterase and NTPDase (ATP and ADP as substrates) activities and a decrease in the 5'-nucleotidase activity. Curcumin was not able to prevent the effect of Cd on acetylcholinesterase activity, but it prevented the effects caused by Cd on NTPDase (ATP and ADP as substrate) and 5'-nucleotidase activities. Increased acetylcholinesterase activity was observed in different brain structures, whole blood and lymphocytes of the Cd-treated group. In addition, Cd increased lipid peroxidation in different brain structures. Higher doses of curcumin were more effective in preventing these effects. These findings show that curcumin prevented the Cd-mediated memory impairment, demonstrating that this compound has a neuroprotective role and is capable of modulating acetylcholinesterase, NTPDase, and 5'-nucleotidase activities. Finally, it highlights the possibility of using curcumin as an adjuvant against toxicological conditions involving Cd exposure. © 2015 Wiley Periodicals, Inc. Environ Toxicol 32: 70-83, 2017. |
| Databáze: | OpenAIRE |
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