Studies on the synthesis of fluorescein-5-isothiocyanate: A fluorescent nanomarker for biosensors

Autor:	V. N. Glushko, L. I. Blokhina, N. Yu. Sadovskaya
Rok vydání:	2015
Předmět:	chemistry.chemical_compound chemistry General chemistry Improved method General Chemistry Fluorescein Solubility Fluorescence Combinatorial chemistry Biosensor eye diseases Fluorescein-5-isothiocyanate
Zdroj:	Russian Journal of General Chemistry. 85:2458-2464
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363215100412
Popis:	A review of the methods of synthesis of fluorescein is given. An improved method of synthesis of a chromatographically pure fluorescein-5-isothiocyanate nanomarker for labeling immunoglobulins is developed, which will allow creation of high-quality biosensors. A unique method of synthesis of 5-aminofluorescein, a precursor of fluorescein-5-isothiocyanate, was also developed. The properties of fluorescein-5-isothiocyanate were studied to find that it exists in two forms having different solubility.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6f48daa689c33710ab7189c2432c1e33 https://doi.org/10.1134/s1070363215100412 Zobrazit plný text záznamu Plný text ve formátu PDF