ChemInform Abstract: Naphthoquinoidal [1,2,3]-Triazole, a New Structural Moiety Active Against Trypanosoma cruzi

Autor:	Rubem F. S. Menna-Barreto, Carlos Alberto De Simone, Antonio V. Pinto, Daniel V. Teixeira, Solange L. de Castro, Vitor F. Ferreira, Eufranio N. Jr. da Silva, Maria do Carmo F. R. Pinto, Raphael S. F. Silva, Maria Cecília B. V. de Souza
Rok vydání:	2008
Předmět:	Chagas disease 1 2 3-Triazole biology Stereochemistry Triazole General Medicine medicine.disease biology.organism_classification chemistry.chemical_compound chemistry Drug development Active compound Triazole derivatives medicine Moiety Trypanosoma cruzi
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200852201
Popis:	[1,2,3]-Triazole derivatives of nor-beta-lapachone were synthesized and assayed against the infective bloodstream trypomastigote form of Trypanosoma cruzi, the etiological agent of Chagas disease. All the derivatives were more active than the original quinones, with IC(50)/1 day values in the range of 17 to 359 microM, the apolar phenyl substituted triazole 6 being the most active compound. These triazole derivatives of nor-beta-lapachone emerge as interesting new lead compounds in drug development for Chagas disease.
Databáze:	OpenAIRE
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