Tissue reaction to and biodegradation of two different microcapsule formulations: DLPLA and DLPLGA
| Autor: | R. L. Robison, G. J. Argentieri, G. E. Visscher |
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| Rok vydání: | 1984 |
| Předmět: | |
| Zdroj: | Proceedings, annual meeting, Electron Microscopy Society of America. 42:200-201 |
| ISSN: | 2690-1315 0424-8201 |
| DOI: | 10.1017/s0424820100111112 |
| Popis: | It was our goal to characterize the tissue response to and biodegradation of microcapsules of lypressin composed of two different polymers. Microcapsules of lypressin were made with the polymer 50:50 poly (DL-lactide-co-glycolide) DLPLGA and poly (D, L-lactide) DLPLA. The work which is presented here compares the in vivo characteristics of these microcapsules as drug delivery systems.For the study using DLPLGA, 14 groups of male rats were administered, as an intramuscular injection (gastrocnemius), microencapsulated lypressin (1%). Injections of microcapsules were examined through Day 63 of the experiment. In the second study using DLPLA, 27 male rats were injected with microcapsules of lypressin (0.4%) and examined at 30 day intervals through 420 days post injection. Light microscopy was used to characterize the tissue reaction to the injected microcapsules. |
| Databáze: | OpenAIRE |
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