A carbositall electrode modified with a SiO2-hemoglobin-gold film as a promising biosensing element

Autor:	T. S. Rozhanchuk, O. A. Egorov, O. Yu. Tananaiko, E. A. Mazurenko
Rok vydání:	2012
Předmět:	Detection limit Chromatography Blood serum Rimantadine Colloidal gold Chemistry Electrode medicine Hemoglobin Biosensor Voltammetry Analytical Chemistry medicine.drug
Zdroj:	Journal of Analytical Chemistry. 67:156-162
ISSN:	1608-3199 1061-9348
Popis:	The analytical prospects of a carbositall electrode modified with a film based on SiO2, hemoglobin (Hb), and gold nanoparticles (CSE SiO2-Hb-Au), prepared by deposition with an electrically generated catalyst, are reported. Hemoglobin on the surface of CSE SiO2-Hb-Au is shown to possess electrocatalytic activity toward dissolved oxygen, giving a rationale for the development of a rapid voltammetric procedure of O2 quantification with a detection limit of 0.1 mg/L. The inhibition activity of a number of nitrogen-containing organic substances to the catalytic current CSE SiO2-Hb-Au is studied. A voltammetric procedure is proposed for determination of the anti-flu drug rimantadine, 1-(1-adamantyl)ethylamine hydrochloride, with a detection limit of 0.4 mg/L. The procedure is applicable to the quantification of rimantadine in blood serum and saliva.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6f3af9e289d57465a3333c6c7a3235e0 https://doi.org/10.1134/s1061934811120070 Zobrazit plný text záznamu Plný text ve formátu PDF