Construction of isoxazolone-fused phenanthridines via Rh-catalyzed cascade C–H activation/cyclization of 3-arylisoxazolones with cyclic 2-diazo-1,3-diketones

Autor:	Yongjia Shang, Tongtong Zhou, Xinwei He, Tingting Yang, Youpeng Zuo, Wangcheng Hu, Shiwen Zhang
Rok vydání:	2021
Předmět:	chemistry.chemical_compound Phenanthridine Chemistry Cascade Organic Chemistry Functional group Intramolecular cyclization Diazo Physical and Theoretical Chemistry Biochemistry Medicinal chemistry Catalysis
Zdroj:	Organic & Biomolecular Chemistry. 19:552-556
ISSN:	1477-0539 1477-0520
DOI:	10.1039/d0ob02310h
Popis:	A Rh(III)-catalyzed cascade C–H activation/intramolecular cyclization of 3-aryl-5-isoxazolones with cyclic 2-diazo-1,3-diketones was described, leading to the formation of isoxazolo[2,3-f]phenanthridine skeletons. The protocol features the simultaneous one-pot formation of two new C–C/C–N bonds and one heterocycle in moderate-to-good yields with good functional group compatibility. It is amenable to large-scale synthesis and further transformation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6f3ac931a52f4efc66d0d0d5f633ed5c https://doi.org/10.1039/d0ob02310h Zobrazit plný text záznamu