| Autor: |
Gennadi I. Mikhasev, Maria E. Mychko, Marina G. Botogova, Elizaveta S. Drozd, Sergei A. Chizhik |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Shell and Membrane Theories in Mechanics and Biology ISBN: 9783319025346 |
| DOI: |
10.1007/978-3-319-02535-3_7 |
| Popis: |
The shell theory-based approach for the elastic analysis of biological cells is proposed. This approach introduces the estimation of the local Young’s modulus of the single cell on the basis of the shell theory and data of the atomic force microscopy (AFM). This method is applicable to evaluate the elastic properties of the cell membrane which stretched under action of the atomic force microscope indenter (AFMI). The cell is represented by a thin shallow spherical shell experiencing the concentrated outward force. The influence of cytoskeleton on the cell deformation is disregarded. Taking into account microscopic sizes of the cell and the indenter tip, the internal nanoscale parameter is introduced into the constitutive equations. On the basis of the experimental data and developed shell model we give a rough estimate of local Young’s modulus for the red blood cell. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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