| Popis: |
The removal of glucose from the blood following massive oraladministration of this sugar involves at least the initial stages ofcarbohydrate metabolism. The rate of its removal, however,may be subject to factors unrelated to carbohydrate metabolismas such.It is the purpose of this article to record experiments that dealwith certain of the factors, both chemical and otherwise, thatdetermine the rate of removal and hence the shape that the bloodsugar curve assumes after glucose ingestion. The meaning of thephenomenon of "low sugar tolerance" and its bearing on thepathology of those disorders in which a lowered sugar tolerance isobserved depends on an understanding of the factors involved inremoving sugar from the blood.In the normal individual the peak of alimentary hyperglycemia,following administration of 100 gm. of glucose, is usually reachedin hour and the blood sugar rarely attains a level in the venousblood higher than 150 mg. per 100 cc. The fall in blood sugarfrom this peak is rapid, ad occurs at a time when glucose is stillbeing actively absorbed from the intestinal tract (1).* The work here reported is part of a series of studies on chronic arthritisin collaboration with Robert Osgood, M.D., of Boston.The expenses of this investigation were defrayed by contributions fromseveral sources, including a number of patients.Presented before the College of Physicians, Philadelphia, June 3, 1925.Obligation should be expressed to Dr. E. G. Peirce for cooperativeassistance in several phases of the work.89 |
