Effects of granulocyte colony-stimulating factor treatment in children and patients with cerebral palsy: a preliminary report
| Autor: | A Kalinowska, Anna Mirska, Dorota Sienkiewicz, Janusz Wojtkowski, K Sochoń, Grażyna Paszko-Patej, Bożena Okurowska-Zawada, Wojciech Kułak, Kamila Okulczyk, E Topór |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty business.industry General Medicine medicine.disease Surgery Cerebral palsy Granulocyte colony-stimulating factor 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Preliminary report medicine business 030217 neurology & neurosurgery |
| Zdroj: | Progress in Health Sciences. 7:78-82 |
| ISSN: | 2083-1617 |
| DOI: | 10.5604/01.3001.0010.1818 |
| Popis: | neuroinflammation and apoptosis in brains affected by cerebral palsy could be therapeutic targets. Granulocyte colony-stimulating factor (G-CSF) exerts anti-inflammatory and antiapoptosis effects and stimulates the proliferation of neural stem and progenitor cells in the brain. Purpose: To assess the efficacy and safety of G-CSF treatment in children and adolescents with CP. Materials and methods: Six patients with spastic tetraplegia CP aged 3-15 years were enrolled in this study. Five patients had GMFCS (Gross Motor Function Classification System) level at V, three children had epilepsy, and three had severe mental retardation. We used the gross motor function measure-66 (GMFM-66) to assess motor function.GCSF (5μg/kg/body/day) was administered subcutaneously for five consecutive days during the four months. The parents also evaluated the physical and mental development of their children. Results: We observed improvement in motor function in patients with CP on the GMFM-66 scale. Parents reported improvement in behavior, speech development, and a decrease in spasticity in children with CP. G-CSF therapy was well-tolerated. No side effects were observed during the study. Conclusions: Our preliminary report suggests that G-CSF treatment improves motor and mental function in patients with CP. Further studies are needed to confirm these observations |
| Databáze: | OpenAIRE |
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