Synergistic T cell modulation by innate and adaptive immune signals (IRC8P.446)
| Autor: | Janice Jun |
|---|---|
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 194:129.10-129.10 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.194.supp.129.10 |
| Popis: | One of the most effective anti-inflammatory agents that has successfully prevented disease in multiple inflammatory disease models is the capsular carbohydrate polysaccharide A (PSA) of the commensal bacteria Bacteroides fragilis. PSA triggers a potent anti-inflammatory response characterized by T cell-dependent IL-10 production, yet little is known about the antigenic mechanism underlying this extraordinarily effective suppressive response. While this effect of PSA is known to require TCR engagement on CD4+ T cells by MHCII presentation of processed PSA by APCs, little else is known about why this engagement, which is common to all conventional T cell antigens, selectively leads to IL-10 production and the inhibition of inflammatory disease. We have taken a reductionist approach to identify the types of antigenic stimuli selectively leading to IL-10 production in T cells and have discovered that innate signals directly on the T cell, independent of the APCs, can modulate IL-10 secretion if the T cell receptor signaling cascade is actively engaged. Moreover, these innate signals leading to IL-10 production are specific for the effector/memory T cell subsets and are not effective within the classically-defined naïve or regulatory T cell populations. This suggests a novel role for T cell-intrinsic innate signals working in conjunction with traditional adaptive signals in inducing a potent IL-10 response with therapeutic ramifications. |
| Databáze: | OpenAIRE |
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