The pro-oxidant effect of dextran sodium sulphate on oxidative stress biomarkers and antioxidant enzymes in Drososphila melanogaster
| Autor: | Johnson O. Titlayo, Ishaya Yohanna Longdet, Aguiyi C. John, Opeyemi Balogun, Augustina Oduje Akinsanmi |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Antioxidant biology Normal diet Chemistry medicine.medical_treatment Sodium chemistry.chemical_element Pharmacology Pro-oxidant medicine.disease_cause Malondialdehyde 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Catalase Toxicity medicine biology.protein Pharmacology (medical) 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | African Journal of Biochemistry Research. 13:82-89 |
| ISSN: | 1996-0778 |
| DOI: | 10.5897/ajbr2019.1042 |
| Popis: | This study sought to evaluate the behavioural and biochemical effects of Dextran Sodium Sulphate (DSS) on the oxidative stress biomarkers and antioxidant enzymes. Drosophila melanogaster (both sexes) of 3 days old were exposed to various DSS incorporated diets at concentrations, 0.5 - 3.0% for a period of 14 days (Survival rate). The second phase comprised of 3 groups; Group I- Control (normal diet), Group II-0.5% DSS, and Group III – 1.0% DSS and fed for 5 days. Climbing activity and biochemical assays were then determined. The survival rates of the flies with concentrations above 1.0% were highly reduced. The induced oxidative stress caused by DSS showed an impaired climbing activity, a significant (p |
| Databáze: | OpenAIRE |
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