EXPRESSION OF CYTOKINES IN THE DORSAL ROOT GANGLION CELL BODY IN AN EXPERIMENTAL MODEL OF ENTRAPMENT NEUROPATHY

Autor:	Koji Ryoke, Soichiro Yamamoto, Mitsuo Ochi, N. Shu, H. Yamaguchi
Rok vydání:	1998
Předmět:	medicine.medical_specialty Adult male Experimental model business.industry Cell General Medicine Anatomy Electrophysiology medicine.anatomical_structure Endocrinology Dorsal root ganglion Internal medicine medicine Entrapment Neuropathy Tube (fluid conveyance) Sciatic nerve business
Zdroj:	Hand Surgery. :175-183
ISSN:	1793-6535 0218-8104
DOI:	10.1142/s021881049800026x
Popis:	An experimental entrapment neuropathy model was produced by wrapping the sciatic nerve with a silicone tube using 54 adult male Wistar rats. We observed the changes in expression of IL-1 and TGF-β1 in the dorsal root ganglion during the formation as well as recovery process after removal of the tube, together with electrophysiological changes. Expression of IL-1 reached its peak 2 months after tubing, while expression of TGF-β1 peaked at 6 months and thereafter slowly decreased. Motor nerve conduction velocity (MNCV) significantly decreased 8 months after tubing. Removal of the silicone tube at 8 months after tubing, induced a significant increase in the level of IL-1 expression at 1 month after the removal, and that in the level of TGF-β1 expression at 2 months after the removal, at which time MNCV began to show a significant recovery. We have concluded from these results that IL-1 and TGF-β1 are deeply involved in the formation as well as the recovery process of entrapment neuropathy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6f0b7e741c1d98295649a3b7fe977bf9 https://doi.org/10.1142/s021881049800026x Zobrazit plný text záznamu