Evidence for spontaneous, low-temperature biradical formation from a highly reactive neocarzinostatin chromophore-thiol conjugate

Autor:	Philip Proteau, Andrew G. Myers
Rok vydání:	1989
Předmět:	chemistry.chemical_classification Colloid and Surface Chemistry Chemistry Diradical Thiol General Chemistry Biochemistry Medicinal chemistry Neocarzinostatin chromophore Catalysis Conjugate Methyl thioglycolate
Zdroj:	Journal of the American Chemical Society. 111:1146-1147
ISSN:	1520-5126 0002-7863
Popis:	Methyl thioglycolate (II) adds to the antitumor antibiotic neocarzinostatin chromophore (I) to initially give (III), which is stable for days under argon at -70 °C. Intermediate (III) rapidly decays at -38 °C and above to produce the major products (VI) and (VII) via the monoradical (IV) and the diradical (V), resp., indicated by 2H incorporation at C-2 and C-6 of (VII) to the extent of 35 ±5% and at C-2 of (VI) to the same degree.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6f08debc1d432788b41f168613c7c3b4 https://doi.org/10.1021/ja00185a064 Zobrazit plný text záznamu