| Autor: | Takanori Asano, Takashi Kinoshita, Katsuyuki Doi |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Oncology
Cisplatin medicine.medical_specialty business.industry medicine.medical_treatment Cancer medicine.disease Pancytopenia Carboplatin Radiation therapy chemistry.chemical_compound Leukemia Otorhinolaryngology chemistry hemic and lymphatic diseases Internal medicine medicine Carcinoma business Chemoradiotherapy medicine.drug |
| Zdroj: | Nippon Jibiinkoka Gakkai Kaiho. 113:556-560 |
| ISSN: | 1883-0854 0030-6622 |
| DOI: | 10.3950/jibiinkoka.113.556 |
| Popis: | Therapy-related myelodysplastic syndrome (t-MDS) and therapy-related leukemia (TRL) are reported increasingly often, and we report two cases of T-MDS after concurrent chemoradiotherapy (CCRT) with oral cancer. Patients underwent CCRT with cisplatin (CDDP) or carboplatin (CBDCA). The interval between primary CCRT and t-MDS was 11 months in 1 case and 14 years in the other. Chromosomal analysis indicated abnormal karyotypes. Platinum has a relatively lower t-MDS risk than alkylating agents or topoisomerase II inhibitors, but our experience supports concurrent use of radiotherapy with platinum affects the risk of t-MDS. If pancytopenia is detected after CCRT, bone marrow and cytogenetic examinations should be conducted to rule out T-MDS. |
| Databáze: | OpenAIRE |
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