Winter vitamin D3 supplementation does not increase muscle strength, but modulates the IGF-axis in young children
| Autor: | Christian Mølgaard, Hanne Hauger, Michael Kristensen, Charlotte Mortensen, Camilla T. Damsgaard |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Vitamin medicine.medical_specialty 030109 nutrition & dietetics Nutrition and Dietetics Vitamin d supplementation business.industry Medicine (miscellaneous) 030209 endocrinology & metabolism Placebo law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Randomized controlled trial chemistry law Internal medicine Vitamin D and neurology Muscle strength Medicine Calcifediol business Linear growth |
| Zdroj: | European Journal of Nutrition. 58:1183-1192 |
| ISSN: | 1436-6215 1436-6207 |
| Popis: | To explore whether muscle strength, the insulin-like growth factor axis (IGF-axis), height, and body composition were associated with serum 25-hydroxyvitamin D [25(OH)D] and affected by winter vitamin D supplementation in healthy children, and furthermore to explore potential sex differences. We performed a double-blind, placebo-controlled, dose–response winter trial at 55oN. A total of 117 children aged 4–8 years were randomly assigned to either placebo, 10, or 20 µg/day of vitamin D3 for 20 weeks. At baseline and endpoint, we measured muscle strength with handgrip dynamometer, fat mass index (FMI), fat free mass index (FFMI), height, plasma IGF-1, IGF-binding protein 3 (IGFBP-3), and serum 25(OH)D. At baseline, serum 25(OH)D was positively associated with muscle strength, FFMI, and IGFBP-3 in girls only (all p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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