Point-by-Point Radiofrequency Ablation Versus the Cryoballoon or a Novel Combined Approach: A Randomized Trial Comparing 3 Methods of Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation (The Cryo Versus RF Trial)

Autor: M Ginks, Mehul Dhinoja, Malcolm Finlay, Laura Richmond, Simon Sporton, Matthew J. Lovell, Victoria Baker, Richard J. Schilling, Ailsa McLean, Mark J. Earley, M. Shoaib Siddiqui, Muzahir H. Tayebjee, Ross J. Hunter, Edward Duncan, Claire Kirkby, Waqas Ullah
Rok vydání: 2015
Předmět:
Zdroj: Journal of Cardiovascular Electrophysiology. 26:1307-1314
ISSN: 1045-3873
Popis: The CRYO Versus RF TrialIntroduction Catheter ablation of paroxysmal AF using the Cryoballoon (CRYO) has yielded similar success rates to conventional wide encirclement using radiofrequency catheter ablation (RFCA), but randomized data are lacking. Pilot data suggested a high success rate with a combined approach (COMBINED) using wide encirclement with RFCA followed by 2 CRYO applications to each vein. We compared these 3 strategies in a randomized controlled trial. Methods and Results Patients undergoing first time paroxysmal AF ablation were randomized to RFCA, CRYO, or COMBINED. Patients were followed up at 3, 6, and 12 months with 7 days of ambulatory ECG monitoring. Success was defined as freedom from arrhythmia without antiarrhythmic drugs after a single procedure. A total of 237 patients were randomized. Success at 1 year was achieved in 47% in the RFCA group, 67% in the CRYO group, and 76% in the COMBINED group (P < 0.001 for RFCA vs. CRYO, P
Databáze: OpenAIRE
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