The Xmas-2 Homologues, the Main Component of the TREX-2 mRNA Export Complex

Autor:	D. V. Kopytova, Elena N. Nabirochkina
Rok vydání:	2020
Předmět:	0303 health sciences Messenger RNA biology Chemistry 030302 biochemistry & molecular biology Protein domain Biophysics RNA General Chemistry General Medicine biology.organism_classification Biochemistry Cell biology 03 medical and health sciences Cytoplasm Transcription (biology) Nucleic acid Melanogaster Eukaryote 030304 developmental biology
Zdroj:	Doklady Biochemistry and Biophysics. 495:325-328
ISSN:	1608-3091 1607-6729
DOI:	10.1134/s1607672920060101
Popis:	TREX-2 complex is responsible for general mRNA export from nucleus to cytoplasm in eukaryote. The main protein of TREX-2 complex of D. melanogaster is protein Xmas-2. Its homologues in yeast and humans are Sac3 and GANP proteins, respectively. All three proteins contain the highly conserved domain Sac3-GANP, which is essential for interaction of TREX-2 complex with mRNA and another protein of the complex, PCID2. We identified two Xmas-2 homologues in D. melanogaster using the Sac3-GANP family domain sequence. These proteins have a common domain responsible for interaction with the PCID2 protein and RNA and are present in other eukaryotes. The function of these proteins is unknown. However, on the basis of their structural organization, we can assume that they interact with nucleic acids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6efac6a7aadaf01df5edd81b5f2957cd https://doi.org/10.1134/s1607672920060101 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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