Early Intervention with Impedance-guided Heart Failure Management Improves Long-term Outcome: insights From the IMPEDANCE-HF Trial
| Autor: | M Kleiner Shochat, M Fudim, M Kazatsker, I Kleiner, J M Weinstein, G Panjrath, O Kobo, A Roguin, S Meisel |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | European Heart Journal. 43 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehac544.1099 |
| Popis: | Background Lung-impedance (LI) guided treatment of heart failure (HF) patients was shown to improve clinical outcomes. Objectives To perform a post-hoc analysis of the IMPEDANCE-HF extended trial in order to explore the mechanism underlying the improved outcome of the LI-guided compared with conventional therapy of HF patients. Methods The study included 290 HF patients with LVEF ≤45% randomized 1:1 to LI-guided or conventional therapy. The normal LI (NLI), representing the dry lung status, was calculated upon enrollment. The level of pulmonary congestion (LPC) was represented by ΔLIR= [(measured LI/NLI)-1] × 100%. Results There were 11473 outpatient visits in the LI-guided group and 10245 visits in the control group during follow-up, or 15.5 and 15.9 visits/patient×year, respectively (p=0.74). The LI-guided patients were on average less congested during follow-up than those in the control group (by 20%, p Conclusion LI-guided diuretic titration prompted earlier, and more frequent diuretic dose increase when the LPC was only beginning to increase and this resulted in a greater decongestive response with better clinical outcomes. Funding Acknowledgement Type of funding sources: None. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|