New merosesquiterpenes from the Vietnamese sponge Hippospongia fistulosa and their cytotoxic activity
| Autor: | Dan Thi Thuy Hang, Vu Kim Thu, Pham Hai Yen, Bui Huu Tai, Phan Van Kiem, Do Thi Trang, Nguyen Xuan Nhiem, Tran Hong Quang |
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| Rok vydání: | 2021 |
| Předmět: |
Chromatography
biology 010405 organic chemistry Chemistry Electrospray ionization Plant Science biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry Hippospongia Sponge Cytotoxic T cell Spectral data Agronomy and Crop Science Human cancer Biotechnology |
| Zdroj: | Phytochemistry Letters. 44:115-119 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2021.06.015 |
| Popis: | Two new merosesquiterpenes, hippomeroterpenes A and B (1 and 2), and four known compounds langconol B (3), 20-demethoxy-20-methylaminodactyloquinone D (4), smenospongidine (5), and smenospongic acid (6) were isolated from the sponge Hippospongia fistulosa. Their structures were determined by extensive analyses of HR ESI MS and NMR spectral data. At concentration of 100 μM, compounds 1-6 exhibited weak cytotoxic effects on Hep-G2, MCF-7, SK-LU-1, and SK-Mel-2 human cancer cells with percentages of dead cells ranging from 8.3 ± 0.3%–36.3 ± 1.5 %. |
| Databáze: | OpenAIRE |
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