New texaphyrin-type expanded porphyrins
| Autor: | Jonathan L. Sessler, Vladimír Král, K. O. Aileen Chin, R. M. Davila, M. C. Hoehner |
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| Rok vydání: | 1996 |
| Předmět: | |
| Zdroj: | Pure and Applied Chemistry. 68:1291-1295 |
| ISSN: | 1365-3075 0033-4545 |
| DOI: | 10.1351/pac199668061291 |
| Popis: | This paper presents the synthesis of several new Schiff-base type expanded porphyrins. A dimeric, tetraazacyclodotetradecane-linked texaphyrin system has been prepared. It, as its gadoliniu'n(II1) adduct, displays a relaxivity in aqueous solution that is roughly 5 times higher than the benchmark texaphyrin monomer currently undergoing human clinical trials as a potential MRI enhancing and X-ray radiation sensitizing drug. Polymeric gadolinium(1II) texaphyrin species, ,derived from poly-L-lysine and a glycosylated poly-L-lysine, have also been prepared, they too display greatly enhanced relaxivities. In work along different lines, the synthesis of an "expanded" texaphyrin has been effected and the construction of two "three dimensional" texaphyrin-inspired targets accomplished. These latter define a new class of pyrrolic cryptands. |
| Databáze: | OpenAIRE |
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