Synthesis of closo-dodecaborate based nucleoside conjugates

Autor:	Ivan A. Godovikov, Vladimir I. Bregadze, Julia Laskova, Andrey Semioshkin, Agnieszka Andrysiak, Zbigniew J. Lesnikowski, Blazej A. Wojtczak
Rok vydání:	2009
Předmět:	Chemistry Stereochemistry Organic Chemistry Dodecaborate Cleavage (embryo) Biochemistry Inorganic Chemistry chemistry.chemical_compound Nucleophile Materials Chemistry Azide Physical and Theoretical Chemistry Thymidine Nucleoside Derivative (chemistry) Conjugate
Zdroj:	Journal of Organometallic Chemistry. 694:1375-1379
ISSN:	0022-328X
DOI:	10.1016/j.jorganchem.2008.12.024
Popis:	The first conjugates of closo-dodecaborate anion with nucleoside-thymidine were synthesized. The nucleophilic cleavage of dioxonium derivative of closo-dodecaborate by 3′,5′-bis(t-butyldimethylsilyl)-thymidine and “click” reaction between B12-based azide and 3N-(4-pentyn-1-yl)thymidine were appeared as convenient approaches towards the synthesis of this new class of nucleoside-based boron cluster conjugates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6ecfc902711673cdd62faae8c1686e71 https://doi.org/10.1016/j.jorganchem.2008.12.024 Zobrazit plný text záznamu Full Text from ScienceDirect