A new water-soluble and mitochondria-targeted fluorescence probe for ratiometric detection of hypochlorous acid in living cells
| Autor: | Li-Jie Zhang, Jun-Ying Miao, Xuan Zhao, Jin-Ting Liu, Xiao Han, Zhen-Zhen Jia, Di Yang, Xiao-Dong He, Li-Li Yu, Bao-Xiang Zhao, Lin-Quan Sun |
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| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Detection limit Hypochlorous acid Iodide Metals and Alloys 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Coumarin 01 natural sciences Combinatorial chemistry Fluorescence 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound Förster resonance energy transfer chemistry Materials Chemistry Moiety Electrical and Electronic Engineering 0210 nano-technology Selectivity Instrumentation |
| Zdroj: | Sensors and Actuators B: Chemical. 276:8-12 |
| ISSN: | 0925-4005 |
| DOI: | 10.1016/j.snb.2018.08.071 |
| Popis: | A new FRET-based ratiometric fluorescence probe for hypochlorous acid was developed. The FRET platform was constructed by a coumarin moiety as the energy donor and (E)-4-(4-(dialkylamino)styryl)-1-methylpyridin-1-ium iodide as the energy acceptor in which double bonds was recognition group for hypochlorous acid. Significantly, the water-soluble probe showed good selectivity, sensitivity, and lower detection limit (89 nM) for hypochlorous acid in optimal working condition. Moreover, the probe with good photo-stability and lower toxicity could successfully detect exogenous and endogenous hypochlorous acid and target mitochondria in living cells. |
| Databáze: | OpenAIRE |
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