Conformational analysis of four spiro[cyclohexane-1,3′-indolin]-2′-one derivatives

Autor:	István Hermecz, Zsolt Böcskei, Benjamin Podányi, Judit Halász, Andrea Sánta-Csutor, Miklós Hanusz, Kálmán Simon
Rok vydání:	2003
Předmět:	Cyclohexane Stereochemistry medicine.drug_class Organic Chemistry Indolin 2 one Receptor antagonist Analytical Chemistry Inorganic Chemistry chemistry.chemical_compound Orally active chemistry X-ray crystallography medicine Moiety Spectroscopy
Zdroj:	Journal of Molecular Structure. 654:187-196
ISSN:	0022-2860
DOI:	10.1016/s0022-2860(03)00226-6
Popis:	SR 121463 is a potent and selective, orally active vasopressin V 2 receptor antagonist. During the synthesis of SR 121463, the formation of the stereochemistry of the cyclohexyl moiety is one of the most important steps. Conformational analysis (via NMR studies and, for cis - 3 , also via X-ray structure determination) of the isomers obtained in this step is reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6ecf157c2cf124d51b15e544d09777ac https://doi.org/10.1016/s0022-2860(03)00226-6 Zobrazit plný text záznamu Full Text from ScienceDirect