A simulation of skin mitochondrial Po 2 in circulatory shock
| Autor: | Bashar N. Hilderink, Reinier F. Crane, Meryem Baysan, Sesmu M. Arbous, Bas van den Bogaard, Egbert G. Mik, Can Ince, Janesh Pillay, Nicole P. Juffermans |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Applied Physiology. 134:1165-1176 |
| ISSN: | 1522-1601 8750-7587 |
| Popis: | This is the first paper to simulate mitochondrial oxygen tension in skin in circulatory shock. The relationships of mitoPo2 with parameters of (microcirculatory) oxygen delivery aid in the understanding of noninvasive bedside measurement of mitoPo2 values and show that mitochondrial oxygen tension is two orders of magnitude higher than classically assumed. The model can be used to enhance clinical trial design investigating mitoPo2 as a resuscitation target in circulatory shock. |
| Databáze: | OpenAIRE |
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