Psammomatous duodenal carcinoid producing somatostatin: Ultrastructural investigation
| Autor: | Gardiner Gw, G. Ilse, T. Moore, K. Kovacs |
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| Rok vydání: | 1987 |
| Předmět: | |
| Zdroj: | Proceedings, annual meeting, Electron Microscopy Society of America. 45:850-851 |
| ISSN: | 2690-1315 0424-8201 |
| Popis: | Somatostatin producing duodenal psammomatous carcinoids, described first by Kaneko et al. in 1979, are rare. We have studied such a tumor by histology, immunohistochemistry, transmission electron microscopy, immunoelectron microscopy and energy dispersive x-ray microanalysis.A 60-year-old woman with attacks of biliary pain underwent cholecystectomy. At surgery, a tumor measuring 3 cm in diameter was discovered in the wall of the duodenum. Transduodenal biopsy revealed a psammomatous carcinoid exhibiting strong immunopositivity for somatostatin. The tumor was removed 4 months later. By histology, the tumor showed a tubular pattern as well as a cribriform arrangement, contained amorphous hematoxylinophil deposits and psammoma bodies which were positive with the von Kossa method and alizarin red. The avidin-biotin-peroxidase complex technique demonstrated positivity for somatostatin, mAB lu-5 (a monoclonal panepithelial antibody), keratin, neuron specific enolase and chromogranin. No immunoreactivity was obtained for ACTH, calcitonin, endorphin, FSH, gastrin, glucagon, GH, insulin, LH, neurophysin, PP, PRL, serotonin, α-subunit, VIP and vasopressin. |
| Databáze: | OpenAIRE |
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