Effects of tianeptine on behavioural and neurochemical responses to immobilization stress
| Autor: | G Curzon, KP Datla |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Open field 030227 psychiatry 03 medical and health sciences Psychiatry and Mental health chemistry.chemical_compound 0302 clinical medicine Endocrinology Neurochemical chemistry Corticosterone Internal medicine medicine Antidepressant Tianeptine 030212 general & internal medicine Serotonin 5-HT receptor Glucocorticoid medicine.drug |
| Zdroj: | European Psychiatry. 8:61s-66s |
| ISSN: | 1778-3585 0924-9338 |
| DOI: | 10.1017/s092493380000540x |
| Popis: | SummaryThe novel antidepressant drug tianeptine had an antidepressant-like effect on a rat model of depression based on the deficit in open field activity observed on the day after 2 h immobilization. Thus, tianeptine (10 mg/kg ip) given 2 h after the end of the immobilization period led to the deficit being opposed. Similar results were obtained using rats previously given 10 mg/kg of the drug per day for 13 days and a final dose 2 h after the end of immobilization. Other workers have found that tianeptine attenuates stress-induced activation of the hypothalamo-pituitary-adrenal axis. Possible relationships between these findings are discussed together with the paradoxical co-existence of the antidepressant properties of tianeptine with its ability to decrease the availability of 5-HT to receptors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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