Alpha-glucosidase inhibitory and antioxidant activities of various extracts of aerial parts of Fagonia indica Burm. F
| Autor: | Atta-ur-Rehman, Nasir Abbas, Abida Latif, Muhammad Naeem Qaisar, Imran Waheed, Atiq-ur-Rehman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Antioxidant biology Traditional medicine DPPH medicine.medical_treatment Flavonoid food and beverages Pharmaceutical Science chemistry.chemical_compound chemistry Polyphenol Alpha-glucosidase biology.protein medicine Maceration (wine) Pharmacology (medical) Maltase IC50 |
| Zdroj: | Tropical Journal of Pharmaceutical Research. 18:791-797 |
| ISSN: | 1596-9827 1596-5996 |
| DOI: | 10.4314/tjpr.v18i4.16 |
| Popis: | Purpose: To investigate in vitro antioxidant and anti-diabetic potentials of Fagonia indica Burm.f. Var. indica in order to provide scientific evidence for its traditional use. Methods: Cold maceration method was employed for the preparation of extracts of aerial parts of the plant using chloroform, n-hexane, methanol and water as solvents. Total flavonoid and polyphenolic content of various extracts were determined by standard methods. The antioxidant and anti-diabetic activities of the extracts were determined using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and in vitro αglucosidase (maltase) inhibitory assays, respectively. Results: Preliminary results indicated the presence of various phytochemicals in the extracts. The chloroform extract exhibited the highest contents of total flavonoids (65.98 ± 1.63 mg QE/g) and polyphenols (26.75 ± 1.09 mg GAE/g). This extract also showed the highest free radical scavenging (64.74 ± 1.43 %) with IC50 value of 34.18 ± 5.57 µg/mL while the methanol extract exerted the highest αglucosidase (maltase) inhibitory activity (45.22 ± 0.46 %) with half-maximal concentration (IC50) of 220.4 ± 0.41 µg/mL. Conclusion: The extracts of the aerial parts of Fagonia indica possess significant anti-diabetic and antioxidant effect, thus justifying the traditional use of the plant for treatment of diabetes. |
| Databáze: | OpenAIRE |
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